Document Report Card

Basic Information

ID: ALA1641449

Journal: Bioorg Med Chem Lett

Title: A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition.

Authors: Chakraborty S, Shah NH, Fishbein JC, Hosmane RS.

Abstract: Synthesis and biochemical inhibition studies of a novel transition state analog inhibitor of guanase bearing the ring structure of azepinomycin have been reported. The compound was synthesized in five-steps from a known compound and biochemically screened against the rabbit liver guanase. The compound exhibited competitive inhibition profile with a K(i) of 16.7±0.5μM.

CiteXplore: 21183343

DOI: 10.1016/j.bmcl.2010.11.109