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ID: ALA1641449
Journal: Bioorg Med Chem Lett
Title: A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition.
Authors: Chakraborty S, Shah NH, Fishbein JC, Hosmane RS.
Abstract: Synthesis and biochemical inhibition studies of a novel transition state analog inhibitor of guanase bearing the ring structure of azepinomycin have been reported. The compound was synthesized in five-steps from a known compound and biochemically screened against the rabbit liver guanase. The compound exhibited competitive inhibition profile with a K(i) of 16.7±0.5μM.
CiteXplore: 21183343