Document Report Card
Basic Information
ID: ALA1641538
Journal: Bioorg Med Chem Lett
Title: Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.
Authors: Sakuma S, Endo T, Kanda T, Nakamura H, Yamasaki S, Yamakawa T.
Abstract: We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis.
CiteXplore: 21112784