Document Report Card

ID: ALA1649207

Journal: Antimicrob Agents Chemother

Title: Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.

Authors: Svetlíková Z, Skovierová H, Niederweis M, Gaillard JL, McDonnell G, Jackson M.

Abstract: Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria.

CiteXplore: 19581465

DOI: 10.1128/aac.00590-09