Document Report Card

ID: ALA1649227

Journal: Antimicrob Agents Chemother

Title: In vitro antiviral activity of V-073 against polioviruses.

Authors: Oberste MS, Moore D, Anderson B, Pallansch MA, Pevear DC, Collett MS.

Abstract: V-073, an enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC50) values ranging from 0.003 to 0.126 microM. Ninety percent of the polioviruses tested were inhibited at EC(50)s of < or = 0.076 microM (MIC90 = 32 ng/ml). V-073 is a promising antiviral candidate for the posteradication management of poliovirus incidents.

CiteXplore: 19635956

DOI: 10.1128/aac.00671-09