Synthesis of lakshminine and antiproliferative testing of related oxoisoaporphines.
Basic Information
ID: ALA1649338
Journal: J Nat Prod
Title: Synthesis of lakshminine and antiproliferative testing of related oxoisoaporphines.
Authors: Castro-Castillo V, Rebolledo-Fuentes M, Theoduloz C, Cassels BK.
Abstract: Lakshminine (6-amino-1-aza-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, 1) is a recent addition to the small family of oxoisoaporphine alkaloids and a member of an even smaller set bearing an amino group at C-6. This rare natural product has now been synthesized in order to have sufficient amounts for biological testing. Lakshminine, its 4-amino isomer (2), their 6- and 4-nitro precursors (8 and 10, respectively), the intermediate 5-methoxy-7H-dibenzo[de,h]quinolin-7-one (6), and the unsubstituted skeleton (11) were tested against normal human fibroblasts and three human solid tumor cell lines. Only compound 10 showed marginal antiproliferative activity.
CiteXplore: 20961068
DOI: 10.1021/np100370g
Patent ID: ┄