Candimine-induced cell death of the amitochondriate parasite Trichomonas vaginalis.
Basic Information
ID: ALA1649373
Journal: J Nat Prod
Title: Candimine-induced cell death of the amitochondriate parasite Trichomonas vaginalis.
Authors: Giordani RB, Vieira Pde B, Weizenmann M, Rosemberg DB, Souza AP, Bonorino C, De Carli GA, Bogo MR, Zuanazzi JA, Tasca T.
Abstract: Candimine (1), an alkaloid from the bulbs of Hippeastrum morelianum, was found to be cytotoxic for the amitochondriate parasite Trichomonas vaginalis. Candimine (1) induced cell death with an unprecedented group of effects that failed to fulfill the criteria for apoptosis and apoptosis-like death already reported in trichomonads. Arrest of the parasite cell cycle, and morphologic and ultrastructural alterations, including marked cytoplasmic vacuolization, were induced by 1. The present findings suggest some similarities to paraptotic cell death, described for multicellular organisms. This study contributes to both a better understanding of the biological effects of 1 and T. vaginalis cell biology.
CiteXplore: 21105684
DOI: 10.1021/np100449g
Patent ID: ┄