Document Report Card

ID: ALA1649563

Journal: Antimicrob Agents Chemother

Title: Nukacin ISK-1, a bacteriostatic lantibiotic.

Authors: Asaduzzaman SM, Nagao J, Iida H, Zendo T, Nakayama J, Sonomoto K.

Abstract: We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K(+) ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.

CiteXplore: 19506061

DOI: 10.1128/aac.01623-08