Document Report Card

ID: ALA1667738

Journal: J Nat Prod

Title: Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.

Authors: Ovenden SP, Nielson JL, Liptrot CH, Willis RH, Tapiolas DM, Wright AD, Motti CA.

Abstract: A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, nakijinol B diacetate (6), and two new sesquiterpene quinones, smenospongines B (4) and C (5), were isolated from the methanol extract of the marine sponge Dactylospongia elegans. Also isolated were the known compounds dactyloquinone B and a 1:1 mixture of ilimaquinone and 5-epi-ilimaquinone. Their structures were determined on the basis of spectroscopic analyses and comparison with literature data. The isolated compounds were assessed for their cytotoxicity against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a normal mammalian cell line (CHO-K1). All compounds were found to have activities in the range 1.8-46 μM and lacked selectivity for tumor versus normal cell lines.

CiteXplore: 21155589

DOI: 10.1021/np100669p