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ID: ALA1667757
Journal: Eur J Med Chem
Title: Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support.
Authors: Gupta M, Paul S, Gupta R.
Abstract: A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in moderate to good yields and are in a state of high purity. Moreover, title compounds have been screened for antifungal activity.
CiteXplore: 21185625