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ID: ALA1667821
Journal: Bioorg Med Chem Lett
Title: Synthesis and galectin-binding activities of mercaptododecyl glycosides containing a terminal β-galactosyl group.
Authors: Murakami T, Yoshioka K, Sato Y, Tanaka M, Niwa O, Yabuki S.
Abstract: Mercaptododecyl glycosides containing a terminal β-galactosyl group were prepared from D-galactose or from D-lactose via hexa-O-acetyl-lactal (10) as a key intermediate. Interactions of these glycolipids (5 kinds) and galectins (β-galactoside binding lectins, 6 species) were evaluated by surface plasmon resonance (SPR) method. High binding responses were observed for the lactoside, 2-deoxy-lactoside, and lactosaminide with some galectins (Gal-3, -4, -8), whereas the galactoside and 2,3-dideoxy-lactoside showed low binding activities.
CiteXplore: 21237642