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ID: ALA1667844
Journal: Bioorg Med Chem Lett
Title: Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers.
Authors: Wang Z, Shi XH, Wang J, Zhou T, Xu YZ, Huang TT, Li YF, Zhao YL, Yang L, Yang SY, Yu LT, Wei YQ.
Abstract: A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC(50) values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.
CiteXplore: 21262571