Document Report Card

ID: ALA1671706

Journal: Antimicrob Agents Chemother

Title: Oligochlorophens are potent inhibitors of Bacillus anthracis.

Authors: Foss MH, Weibel DB.

Abstract: Bacterial cytoskeletal proteins are an emerging set of targets for antibiotic development. This paper describes oligochlorophen analogs based on the monomer 4-chloro-2,6-dimethylphenol as antimicrobial agents against Bacillus anthracis. The most potent analogs have a MIC of 160 to 320 nM against B. anthracis and may target the cytoskeletal protein FtsZ. B. anthracis develops resistance to the oligochlorophens at a rate of 4.34 x 10(-10) per generation, which is approximately 10-fold lower than that of commercial antibiotics used to treat this human pathogen.

CiteXplore: 20566769

DOI: 10.1128/aac.00067-10