Short cationic antimicrobial peptides interact with ATP.

ID: ALA1671728

Journal: Antimicrob Agents Chemother

Title: Short cationic antimicrobial peptides interact with ATP.

Authors: Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE.

Abstract: The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.

CiteXplore: 20660668

DOI: 10.1128/aac.01664-09

Patent ID: ┄