Basic Information
ID: ALA1681646
Journal: Bioorg Med Chem Lett
Title: Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation.
Authors: Kim TH, Kim JK, Ito H, Jo C.
Abstract: The naturally occurring yellow dietary diarylheptanoid curcumin (1) was converted by γ-ray to two new γ-lactones, curculactones A (2) and B (3), as well as four known transformates, erythro-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (4), threo-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (5), vanillic acid (6), and vanillin (7). The structures of the two new γ-lactone derivatives were elucidated on the basis of spectroscopic methods. The steroisomeric phenylpropanoids 4 and 5 exhibited significantly enhanced inhibitory activity against pancreatic lipase when compared to parent curcumin.
CiteXplore: 21282056
DOI: 10.1016/j.bmcl.2010.12.122
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets