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ID: ALA1681653
Journal: Bioorg Med Chem Lett
Title: Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.
Authors: Rasmussen TS, Allman S, Twigg G, Butters TD, Jensen HH.
Abstract: The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor of glucocerebrosidase (GCase) to give an IC(50) value of 0.4 μM, being 250- and 150-fold better than N-butyl and N-nonyl noeurostegine, respectively. The parent noeurostegine and its N-butyl and N-nonyl alkylated congeners were also tested as pharmacological chaperones against a N370S GCase mutant. Of these, only noeurostegine, was found to increase enzyme activity, which in potency was comparable to that previously reported for isofagomine.
CiteXplore: 21292481