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ID: ALA1681664
Journal: Bioorg Med Chem Lett
Title: Specific biotinylation of IMP dehydrogenase.
Authors: Hoefler BC, Gollapalli DR, Hedstrom L.
Abstract: IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH.
CiteXplore: 21295473