Discovery of new inhibitor for PDE3 by virtual screening.

ID: ALA1681753

Journal: Bioorg Med Chem Lett

Title: Discovery of new inhibitor for PDE3 by virtual screening.

Authors: Kim KY, Lee H, Yoo SE, Kim SH, Kang NS.

Abstract: In this work, we tried to find a new scaffold for a PDE3 using virtual screening for the obesity treatment. We first analyzed structural features for the known PDE3 inhibitors based on the PDE3B-ligand complex structure, and then carried out a docking study based on PDE3B 3D structure. We obtained a compound as potent PDE3 inhibitor stimulating lipolysis in murine adipocytes and human adipocytes.

CiteXplore: 21330134

DOI: 10.1016/j.bmcl.2011.01.120

Patent ID: ┄