Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach.
Basic Information
ID: ALA1681773
Journal: Bioorg Med Chem Lett
Title: Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach.
Authors: Yang SX, Gao JM, Zhang Q, Laatsch H.
Abstract: A new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin D (2) and pochonin N (3), has been isolated from the cultures of Fusarium sp. LN-10, an endophytic fungus originated from the leaves of Melia azedarach. Their structures were established on the basis of extensive spectroscopic analyzes including 1D- and 2D- NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) experiments. Compounds 1-3 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina).
CiteXplore: 21353539
DOI: 10.1016/j.bmcl.2010.12.043
Patent ID: ┄