2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study.
Basic Information
ID: ALA1759840
Journal: Bioorg Med Chem Lett
Title: 2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study.
Authors: Chen Q, Bryant VC, Lopez H, Kelly DL, Luo X, Natarajan A.
Abstract: The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity relationship (SAR). This resulted in the identification of a bisfuranylquinoxalineurea analog (7c) that has low micromolar potency against the panel of cancer cell lines. We also show that cells treated with quinoxalineurea 7c results in caspase 3/7 activation, PARP cleavage and Mcl-1 dependent apoptosis.
CiteXplore: 21376584
DOI: 10.1016/j.bmcl.2011.02.055
Patent ID: ┄