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ID: ALA1759859
Journal: Bioorg Med Chem Lett
Title: Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase.
Authors: Chung SC, Jang KH, Park J, Ahn CH, Shin J, Oh KB.
Abstract: Sargachromanols A-P (1-16), 16 meroterpenoids of the chromene class isolated from the brown alga Sargassum siliquastrum, were evaluated for their inhibitory activities toward Na(+)/K(+) ATPase from porcine cerebral cortex and isocitrate lyase (ICL) from Candida albicans. These studies led to the identification of compounds 4, 6, 8, and 12 as potent Na(+)/K(+) ATPase inhibitors. Compounds 12, 13, and 16 exhibited moderate ICL inhibitory activity. Compound 12 also showed weak antibacterial activity. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.
CiteXplore: 21377877