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ID: ALA1759900
Journal: Bioorg Med Chem Lett
Title: Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells by lignans isolated from Euonymus alatus leaves and twigs.
Authors: Jeong EJ, Cho JH, Sung SH, Kim SY, Kim YC.
Abstract: The 80% methanolic extract of Euonymus alatus leaves and twigs afforded three new lignans, (-)-threo-4,9,4',9'-tetrahydroxy-3,7,3',5'-tetramethoxy-8-O-8'-neolignan (1), (-)-threo-4,9,4',9'-tetrahydroxy-3,5,7,3'-tetramethoxy-8-O-8'-neolignan (2), (7R,8R,7'R)-(+)-lyoniresinol (3), together with seventeen known lignans (4-20). The structures of 1-20 were elucidated by extensive 1D and 2D spectroscopic methods including (1)H NMR, (13)C NMR, (1)H-(1)H COSY, HMQC, HMBC and NOESY. All the isolated compounds except for dilignans (19 and 20) significantly inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells.
CiteXplore: 21435874