The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Basic Information

ID: ALA1759901

Journal: Bioorg Med Chem Lett

Title: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Authors: Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.

Abstract: By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.

CiteXplore: 21398123

DOI: 10.1016/j.bmcl.2011.02.061

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