C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

ID: ALA1759920

Journal: Bioorg Med Chem Lett

Title: C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

Authors: Patel P, Gore V, Powell WS, Rokach J.

Abstract: The total synthesis of C(20)-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation-resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized these cells to subsequent exposure to 5-oxo-ETE.

CiteXplore: 21377873

DOI: 10.1016/j.bmcl.2011.02.021

Patent ID: ┄