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ID: ALA1759921
Journal: Bioorg Med Chem Lett
Title: N5-phosphonoacetyl-L-ornithine (PALO): a convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae.
Authors: Johnson B, Steadman R, Patefield KD, Bunker JJ, Atkin AL, Dussault P.
Abstract: A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.
CiteXplore: 21421312