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ID: ALA1759986
Journal: Bioorg Med Chem Lett
Title: Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties.
Authors: Park S, Hyun S, Do SI, Yu J.
Abstract: We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of α-glucosidase. The best substrate showed 150-fold improved K(m) value relative p-acetaminophenyl-α-D-glucopyranoside for α-glucosidase from Bacillus stearothermophillus. Using information from the complementary, we synthesized sp-WY and β-Glc-sp-WY, which selectivity inhibited the cognate enzyme.
CiteXplore: 21397496