Discovery of small molecule human FPR1 receptor antagonists.

ID: ALA1770079

Journal: Bioorg Med Chem Lett

Title: Discovery of small molecule human FPR1 receptor antagonists.

Authors: Unitt J, Fagura M, Phillips T, King S, Perry M, Morley A, MacDonald C, Weaver R, Christie J, Barber S, Mohammed R, Paul M, Cook A, Baxter A.

Abstract: The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.

CiteXplore: 21486695

DOI: 10.1016/j.bmcl.2011.03.049

Patent ID: ┄