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ID: ALA1772941
Journal: Bioorg Med Chem Lett
Title: Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Authors: Wang L, Hubert JA, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, MacNeil DJ, Weber AE, Edmondson SD.
Abstract: A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist.
CiteXplore: 21493064