Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
Basic Information
ID: ALA1773058
Journal: Bioorg Med Chem
Title: Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
Authors: Kamal A, Kumar BA, Suresh P, Juvekar A, Zingde S.
Abstract: A series of new 4β-carbamoyl epipodophyllotoxin analogues have been synthesized and evaluated for their anticancer activity against eleven cancer cell lines including Zr-75-1, MCF7, KB, Gurav, DWD, Colo 205, A-549, Hop62, PC3, SiHa and A-2780. Most of the compounds exhibited better growth-inhibition activities against tested cell lines than that of etoposide. Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide.
CiteXplore: 21489802
DOI: 10.1016/j.bmc.2011.03.030
Patent ID: ┄