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ID: ALA1777770
Journal: Bioorg Med Chem Lett
Title: Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.
Authors: Suzuki T, Tanaka R, Hamada S, Nakagawa H, Miyata N.
Abstract: To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5-8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported.
CiteXplore: 20056538