The discovery of novel calcium sensing receptor negative allosteric modulators.
Basic Information
ID: ALA1781979
Journal: Bioorg Med Chem Lett
Title: The discovery of novel calcium sensing receptor negative allosteric modulators.
Authors: Balan G, Bauman J, Bhattacharya S, Castrodad M, Healy DR, Herr M, Humphries P, Jennings S, Kalgutkar AS, Kapinos B, Khot V, Lazarra K, Li M, Li Y, Neagu C, Oliver R, Piotrowski DW, Price D, Qi H, Simmons HA, Southers J, Wei L, Zhang Y, Paralkar VM.
Abstract: The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.
CiteXplore: 19442519
DOI: 10.1016/j.bmcl.2009.04.044
Patent ID: ┄