Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.

ID: ALA1782000

Journal: Bioorg Med Chem

Title: Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.

Authors: Liaras K, Geronikaki A, Glamočlija J, Cirić A, Soković M.

Abstract: As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties. Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates.

CiteXplore: 21524583

DOI: 10.1016/j.bmc.2011.04.007

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