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ID: ALA1782036
Journal: Bioorg Med Chem Lett
Title: Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.
Authors: Zhou J, Duan L, Chen H, Ren X, Zhang Z, Zhou F, Liu J, Pei D, Ding K, Ding K.
Abstract: 2-Piperazinyl naphthoquinones (2) and 2-piperidinyl naphthoquinones (3) were designed and synthesized as new cytotoxic and apoptosis inducing agents by utilizing the anti-parasite drug atovaquone as lead compound. Several compounds displayed significantly improved cytotoxic activities against a panel of cancer cell lines than that of atovaquone. These compounds also induced apoptosis through activating pro-apoptotic caspases 9 and 3.
CiteXplore: 19632833