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ID: ALA1795321
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists.
Authors: Xia J, Song J, Zhen L, Zhang X, Lei X, Zheng L, Wang Q, Sun H.
Abstract: A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid (4) displays comparable potency with ambrisentan (1), and warrants further investigation.
CiteXplore: 21652209