Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

ID: ALA1799927

Journal: Bioorg Med Chem Lett

Title: Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Authors: Belanger DB, Curran PJ, Hruza A, Voigt J, Meng Z, Mandal AK, Siddiqui MA, Basso AD, Gray K.

Abstract: The synthesis and structure-activity relationships (SAR) of novel, potent imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo[1,2-a]pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.

CiteXplore: 20674350

DOI: 10.1016/j.bmcl.2010.07.008

Patent ID: ┄