Azaphilones from the endophyte Chaetomium globosum.
Basic Information
ID: ALA1799936
Journal: J Nat Prod
Title: Azaphilones from the endophyte Chaetomium globosum.
Authors: Borges WS, Mancilla G, Guimarães DO, Durán-Patrón R, Collado IG, Pupo MT.
Abstract: Six new azaphilones, 5'-epichaetoviridin A (7), 4'-epichaetoviridin F (9), 12β-hydroxychaetoviridin C (10), and chaetoviridins G-I (11-13), and six known azaphilones, chaetoviridins A-E (1-5) and 4'-epichaetoviridin A (8), were isolated from the endophytic fungus Chaetomium globosum cultivated in PDB medium for 21 days. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses. The structure of compound 1 was confirmed by single-crystal X-ray diffraction analysis. The absolute configurations of compounds 4, 7, 8, and 12 were determined using Mosher's method. The antibiotic activity of the compounds was evaluated using an in vivo Caenorhabditis elegans infection model.
CiteXplore: 21548578
DOI: 10.1021/np200110f
Patent ID: ┄