SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Basic Information
ID: ALA1799955
Journal: Bioorg Med Chem Lett
Title: SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Authors: Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R.
Abstract: Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited Coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series.
CiteXplore: 21684160
DOI: 10.1016/j.bmcl.2011.05.070
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