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ID: ALA1799991
Journal: Bioorg Med Chem Lett
Title: Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
Authors: Lee J, Kim KH, Jeong S.
Abstract: A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.
CiteXplore: 21684737