An optimized immunoaffinity fluorescent method for natural product target elucidation.

ID: ALA1800035

Journal: J Nat Prod

Title: An optimized immunoaffinity fluorescent method for natural product target elucidation.

Authors: Yu WL, Guizzunti G, Foley TL, Burkart MD, La Clair JJ.

Abstract: Understanding the mode of action of small molecules is an integral facet of drug discovery. We report an optimized immunoaffinity fluorescent method that allows one to conduct parallel studies at both the cellular and molecular level using a single probe construct. Viability of the method has been evaluated analytically and applied using glycyrrhetic acid as a model.

CiteXplore: 20836515

DOI: 10.1021/np100371k

Patent ID: ┄