Synthesis and antiglycation potentials of bergenin derivatives.
Basic Information
ID: ALA1806470
Journal: Bioorg Med Chem Lett
Title: Synthesis and antiglycation potentials of bergenin derivatives.
Authors: Vijaya Kumar T, Tiwari AK, Robinson A, Suresh Babu K, Sateesh Chandra Kumar R, Anand Kumar D, Zehra A, Madhusudna Rao J.
Abstract: Bergenin (1), major bioactive compound isolated from methanolic extract of Mallotus philippinensis, displayed moderate AGE inhibition activity (IC(50)=186.73 μM). A series of derivatives of bergenin (3a-k) containing variety of aromatic acids were synthesized under mild conditions by modification of sugar part. Selective esterification of hydroxyl groups on the sugar part enhanced antiglycation potential of bergenin. Compounds 3j and 3k exhibited potent antiglycation activity with the IC(50) values of 60.75 and 12.28 μM, respectively.
CiteXplore: 21752643
DOI: 10.1016/j.bmcl.2011.04.131
Patent ID: ┄