New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
Basic Information
ID: ALA1806480
Journal: Eur J Med Chem
Title: New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
Authors: Mohamed MS, Kamel R, Fatahala SS.
Abstract: The Pyrrole derivatives Ia-d were prepared and utilized for the preparation of pyrrolo[2,3-d]pyrimidine derivatives IIa-c, III, IVa-e, V and VIIIa-c; pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine VI and pyrrolo[4,3e][1,2,4]triazolo[1,5-c]pyrimidine derivative derivatives VIIa-c. These some newly synthesized compounds were examined for their in vitro antimicrobial activity and in vivo anti-inflammatory. Result indicated that these compounds showed promising anti-inflammatory activity in comparison to ibuprofen (the standard anti-inflammatory drug). The structure-activity relationships (SAR) and anti-inflammatory activities of these compounds are also discussed in this paper.
CiteXplore: 21549457
DOI: 10.1016/j.ejmech.2011.04.034
Patent ID: ┄