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ID: ALA1811764
Journal: Bioorg Med Chem Lett
Title: Structure-activity studies of RNA-binding oxazolidinone derivatives.
Authors: Maciagiewicz I, Zhou S, Bergmeier SC, Hines JV.
Abstract: The structure-activity relationship of a series of oxazolidinones binding to T-box riboswitch antiterminator RNA has been investigated. Oxazolidinones differentially substituted at C-5 were prepared and the ligand-induced fluorescence resonance energy transfer (FRET) changes in FRET-labeled antiterminator model RNA were assayed. Both qualitative and quantitative analysis of the structure-activity relationship indicate that hydrogen bonding and hydrophobic properties play a significant role in ligand binding.
CiteXplore: 21733684