Document Report Card

ID: ALA1811820

Journal: J Nat Prod

Title: Vicenin-2, a potential anti-inflammatory constituent of Urtica circularis.

Authors: Marrassini C, Davicino R, Acevedo C, Anesini C, Gorzalczany S, Ferraro G.

Abstract: Vicenin-2 (1), a flavonoid glycoside, was isolated and identified from an ethanol extract of the aerial parts of Urtica circularis. This crude extract was found to possess significant anti-inflammatory activity in a carrageenan-induced rat hind paw edema model (41.5% inhibition at a dose of 300 mg/kg; ip). The effects of 1 on several inflammatory mediators were investigated. In cultured murine macrophages, this compound modified LPS-induced total nitrite and TNF-α production, in addition to the LPS-induced translocation of the nuclear factor NF-κB.

CiteXplore: 21608987

DOI: 10.1021/np100937e