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ID: ALA1811829
Journal: Bioorg Med Chem
Title: Discovery of selective indole-based prostaglandin D₂ receptor antagonist.
Authors: Iwahashi M, Shimabukuro A, Onoda T, Matsunaga Y, Okada Y, Matsumoto R, Nambu F, Nakai H, Toda M.
Abstract: A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.
CiteXplore: 21737285