Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors.

Basic Information

ID: ALA1811910

Journal: Bioorg Med Chem

Title: Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors.

Authors: Hassan HM, Sallam AA, Mohammed R, Hifnawy MS, Youssef DT, El Sayed KA.

Abstract: Sarcophine (1) is a bioactive cembranoid diterpene isolated from the Red Sea soft coral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1's anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer cell lines. This encouraged further semisynthestic optimizations to improve its activity and establish a preliminary structure-activity relationship. Eight new and five known semisynthetic analogues were generated. These compounds were evaluated for their ability to inhibit growth, proliferation, and migration of the prostate and breast metastatic cancer cell lines PC-3 and MDA-MB-231, respectively. Most analogues exhibited enhanced antimigratory activity.

CiteXplore: 21775154

DOI: 10.1016/j.bmc.2011.06.060

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