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ID: ALA1817605
Journal: Bioorg Med Chem Lett
Title: Development of a highly selective fluorescence probe for alkaline phosphatase.
Authors: Kawaguchi M, Hanaoka K, Komatsu T, Terai T, Nagano T.
Abstract: We have developed the first highly selective fluorescence probe for alkaline phosphatase (ALP), TG-mPhos. This probe shows selectivity for ALP over protein tyrosine phosphatase and protein serine/threonine phosphatase. Our previously developed TG-Phos, which has a phenolic phosphate linkage in place of the alcoholic phosphate linkage of TG-mPhos, lacks this selectivity. TG-mPhos should enable precise fluorescence imaging of ALP activity in biological applications.
CiteXplore: 21482108