Document Report Card

ID: ALA1817623

Journal: J Nat Prod

Title: Sesterterpenes from the tropical sponge Coscinoderma sp.

Authors: Bae J, Jeon JE, Lee YJ, Lee HS, Sim CJ, Oh KB, Shin J.

Abstract: Eight new sesterterpenes (2, 5, and 10-15), including structurally related pentaprenyl hydroquinones (2 and 5), and seven known ones of the same structural classes were isolated from the sponge Coscinoderma sp., collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lyase, sortase A, and Na+/K+-ATPase; significant structure-activity relationships were evident.

CiteXplore: 21827183

DOI: 10.1021/np200492k