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ID: ALA1817642
Journal: Eur J Med Chem
Title: Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain.
Authors: Shingate BB, Hazra BG, Salunke DB, Pore VS, Shirazi F, Deshpande MV.
Abstract: Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.
CiteXplore: 21664730