Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.

ID: ALA1821559

Journal: J Nat Prod

Title: Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.

Authors: Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.

Abstract: Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively).

CiteXplore: 21806011

DOI: 10.1021/np2005083

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