Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.
Basic Information
ID: ALA1821628
Journal: J Nat Prod
Title: Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.
Authors: Huang YT, Chang HS, Wang GJ, Cheng MJ, Chen CH, Yang YJ, Chen IS.
Abstract: Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.
CiteXplore: 21846089
DOI: 10.1021/np200279r
Patent ID: ┄