The activity of dispiro peroxides against Fasciola hepatica.

ID: ALA1828617

Journal: Bioorg Med Chem Lett

Title: The activity of dispiro peroxides against Fasciola hepatica.

Authors: Wang X, Zhao Q, Vargas M, Dong Y, Sriraghavan K, Keiser J, Vennerstrom JL.

Abstract: Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.

CiteXplore: 21802291

DOI: 10.1016/j.bmcl.2011.07.024

Patent ID: ┄